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Coronary Artery Bypass Grafting Surgery Off- or On-pump

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Offer Details: INTRODUCTION: CORONARY is a large international randomised controlled trial comparing coronary artery bypass graft (CABG) surgery done with and without a bypass pump. Compared with on-pump, off-pump surgery may prevent acute kidney injury (AKI) in the short term and may better preserve kidney function 1 year following surgery. See more ...

Kidney Function After Off-Pump or On-Pump Coronary Artery

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Offer Details: Jun 04, 2014 · Patients were randomized to receive CABG surgery either with a beating-heart technique (off-pump) or with cardiopulmonary bypass (on-pump). From January 2010 to November 2011, 2932 patients (from 63 sites in 16 countries) from CORONARY were enrolled into a kidney function substudy to record serum creatinine concentrations during the ... See more ...

Influence Of Renal Function On The Efficacy and Safety Of

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Offer Details: Off Label Use: Dabigatran etexilate is an oral direct thrombin inhibitor approved for the prevention of stroke in patients with atrial fibrillation and (outside the US) for prevention of venous thromboembolism in patients undergoing total hip or knee replacement. This presentation includes discussion of the following off-label use of dabigatran ... See more ...

Clinical Predictors of Intracranial Bleeding in Older

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Offer Details: Inclusion criteria were a fall on level ground, off a bed, chair, or toilet, or from one or two steps within 48 hours. MEASUREMENTS: Emergency physicians recorded predefined clinical findings on initial assessment. The primary outcome was intracranial bleeding, diagnosed either by computed tomography at the index visit or within 42 days. ... See more ...

An Inventory Problem with Two Randomly Available Suppliers

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Offer Details: The OFF periods for each supplier have a general distribution. In analogy with queuing notation, we call this an E s 1 [ E s 2 ]/ G 1 [ G 2 ] system. Since the resulting stochastic process is non-Markovian, we employ the “method of stages” to transform the process into a Markovian one, albeit at the cost of enlarging the state space. See more ...

Functional studies of nerve projections in the canine

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Offer Details: "Off" contractions, those that followed cessation of field stimulation, occurred at higher frequencies of field stimulation proximally and distally near the site of field stimulation and were blocked by atropine but not by naloxone or hexamethonium. The effects of all agents given locally extended beyond the … See more ...

Michael Walsh - McMaster Experts

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Offer Details: Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY): kidney substudy analytic protocol of an international randomised controlled trial. BMJ … See more ...

Richard Whitlock - McMaster Experts

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Offer Details: Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days. New England Journal of Medicine. 366:1489-1497. 2012. The Use of Transcutaneous Oximetry to Predict Healing Complications of Lower Limb Amputations: A Systematic Review and Meta-analysis ... See more ...

Accuracy of C-reactive protein, procalcitonin, serum

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Offer Details: No cut-off resulted in satisfactory sensitivity or specificity. CONCLUSIONS: Accuracy of traditional (CRP, PCT) and newly proposed biomarkers (SAA, NP) and ratios of CRP/NP and SAA/NP was too low to help diagnosing pneumonia in the elderly. CRP had the highest … See more ...

Geoffrey Norman - McMaster Experts

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Offer Details: Sample size calculations: should the emperor's clothes be off the peg or made to measure?. British Medical Journal BMJ (Clinical research ed.). 345:e5278-e5278. 2012. First move the goal posts, and then change the team: an ... See more ...

Medical School Admissions: Revisiting the Veracity and

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Offer Details: Five off-site ABS questions were completed, plus eight on-site questions. On-site ABS questions were answered in variable timing conditions. ABS ratings were compared across sites and time allowed for completion. RESULTS: Off-site ABS ratings were higher than on-site ratings, and the two sets of ratings were uncorrelated with one another. See more ...

Gemcitabine, Dexamethasone, Cisplatin (GDP) Compared to

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Offer Details: abstract . Abstract Abstract 745 Background: The optimum chemotherapy combination prior to autologous stem cell transplantation (ASCT) for patients with relapsed or refractory aggressive non-Hodgkin lymphomas (NHL) has not been defined. We previously established the safety and efficacy of outpatient treatment with GDP in a phase II study (Crump et al, Cancer 2004) leading to this phase III ... See more ...

Sublingual apomorphine (APL-130277) for the acute

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Offer Details: INTRODUCTION: OFF episodes negatively impact quality of life in patients with Parkinson's disease (PD). There remains a need for an acute, effective, noninvasive treatment. BACKGROUND: APL-130277 is a sublingually administered apomorphine oral strip. METHODS: The authors conducted a phase 2, open-label, proof-of-concept study. See more ...

Patients’ values and preferences of the expected efficacy

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Offer Details: We will determine each patient's VP using a trade-off and anticipated regret exercises. Our primary outcomes for the combined surveys will be: (1) the minimal delay time in the need for THA surgery that patients would find acceptable to undertaking HA, (2) patients’ satisfaction with the amount of information provided in the health scenarios ... See more ...

Use of serum C reactive protein and procalcitonin

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Offer Details: Apr 30, 2013 · Addition of CRP at the optimal cut off of >30 mg/L increased the ROC area to 0.77 (0.73 to 0.81) and improved the diagnostic classification (net reclassification improvement 28%). In the 1556 patients classified according to symptoms, signs, and CRP >30 mg/L as "low risk" ( 2.5%) for pneumonia, the prevalence of pneumonia was 2%. See more ...

A Multi‐component All‐DNA Biosensing System Controlled by

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Offer Details: Jun 22, 2020 · The 4WJ can be configured to produce either a turn-off or turn-on switch to control the degree of CHA, allowing target concentration to be determined in a quantitative manner. We demonstrate this approach by creating a sensor for E. coli that could detect as low as 50 E. coli cells mL-1 within 85 min and offers an amplified bacterial detection ... See more ...

Pelvic floor morphometry: a predictor of success of pelvic

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Offer Details: Using a cut-off point of 11.4 mm, participants' response to PFM training was predicted with a sensitivity of 77% and a specificity of 83%. Incontinent women with a urethro-vesical junction height above this threshold were 35% more likely to respond to PFM training (OR 1.35; 95% CI: 1.08-1.67). See more ...

Philip Devereaux - McMaster Experts

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Offer Details: Off-Pump or On-Pump Coronary-Artery Bypass Grafting REPLY. New England Journal of Medicine. 367:578-578. 2012; Secular trends in acute dialysis after elective major surgery — 1995 to 2009. CMAJ. 184:1237-1245. 2012 See more ...

A Case for Clarity, Consistency, and Helpfulness: State-of

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Offer Details: Mar 01, 2008 · CONCLUSIONS: GRADE describes the quality of the evidence using four levels: very low, low, moderate, and high quality. Recommendations can be either strong ("we recommend") or weak ("we suggest"), and this strength reflects the confidence that guideline panel members have that patients who receive recommended care will be better off. See more ...

Suzette Salama - McMaster Experts

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Offer Details: Sample size calculations: should the emperor's clothes be off the peg or made to measure?.British Medical Journal BMJ (Clinical research ed.).345:e5278-e5278. See more ...

The clinical utility of naturalistic action test in

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Offer Details: Using the Youden index, we determined a Naturalistic Action Test cut-off score of ≥11 for Mild Cognitive Impairment in our study (PPV 50%, NPV 91%, sensitivity 78%, specificity 73% and accuracy of 74%). There was discrepancy in 18 patients using the new cut-off point (≥11 for Mild Cognitive Impairment vs ≤10 for dementia). See more ...

Influence Of Age On The Efficacy and Safety Of Dabigatran

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Offer Details: abstract . Abstract Background In the RE-COVER and RE-COVER II trials, a fixed dose of dabigatran etexilate was as effective as warfarin for prevention of recurrent VTE and was associated with a lower risk of bleeding. It is not known whether this efficacy and difference in bleeding rates is maintained in older patients. Objectives Older patients may be at greater risk of bleeding and/or VTE. See more ...

Classification of general and personal semantic details in

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Offer Details: Under standard AI instructions, external details were intended to capture off-topic utterances and were not intended as a direct measure of semantic abilities. Future investigations concerned with semantic processing in aging and in dementia could modify standard instructions of the AI to directly probe semantic content. authors See more ...

Quality of life of patients with ulcerative colitis

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Offer Details: Two instruments, the time trade-off technique and direct questioning of objectives, were used to assign the worth (utility) of the perceived quality of life of patients who had ulcerative colitis requiring surgery. Utilities ranged from 0 to 1 with 0 signifying death and 1 signifying full health. Two groups of … See more ...

Richard H Hunt - McMaster Experts

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Offer Details: Acid Suppression for Reflux Disease: “Off-the-Peg” or a Tailored Approach?. Clinical Gastroenterology and Hepatology. 10:210-213. 2012. Altered physiology of acid secretion in depression-prone Flinders rats results in exacerbated NSAID and stress-induced gastric damage. Neurogastroenterology and Motility ... See more ...

Enhanced prediction of breast cancer prognosis by

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Offer Details: Extracts from 952 primary breast carcinomas were assayed for PSA and p53 by quantitative enzyme-linked immunosorbent assays (ELISAs) developed by the authors. Concentrations of each marker were classified as negative or positive on the basis of median and 30th percentile cut-off points for p53 and PSA respectively. See more ...

Salim Yusuf - McMaster Experts

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Offer Details: Off-Pump or On-Pump Coronary-Artery Bypass Grafting. New England Journal of Medicine. 369:194-197. 2013. Dabigatran Versus Warfarin. Stroke. 44:1891-1896. 2013. Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of ... See more ...

Anna Danielova - McMaster Experts

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Offer Details: Tracking Stock or Spin-Off Determinants of Choice. Financial Management. 37:125-139. 2008. Teaching. teaching activities . Applied Corporate Finance - COMMERCE 4FA3, Instructor 2017; Valuation for Finance Professionals - COMMERCE 4FB3, Instructor ... See more ...

Gastroenterology & Hepatology Concept

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Offer Details: subject area of "Topical" phase effects of acetylsalicylic acid on human small bowel epithelium: Inhibition of oxidative phosphorylation and increased tight junction permeability See more ...

Phase I study to determine the safety and pharmacokinetics

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Offer Details: Dose-limiting toxicities (DLTs), safety, pharmacokinetics and tumor response were also evaluated. PATIENTS AND METHODS: In this open-label, phase I, dose-escalation study, BAY 43--9,006 was administered orally in repeated cycles of 35 days (28 days on/7 days off). Eight doses were investigated: from 50 mg every fourth day to 600 mg twice daily. See more ...

C-reactive protein for prediction of atrial fibrillation

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Offer Details: When a predefined CRP cut-off of 3 mg/l was applied, patients with CRP levels of 3 mg/l or above had a higher risk of AF recurrence than those with levels below (aHR, 1.44; 95% CI, 1.06–1.95; P = 0.019). See more ...

Alexandra Papaioannou - McMaster Experts

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Offer Details: The bisphosphonates in the treatment of osteoporosis Expected Benefits, potential harms and therapeutic time off. Canadian Family Physician. 60:E197-E207. 2014; Too Fit To Fracture: exercise recommendations for individuals with osteoporosis or osteoporotic … See more ...

How different are composite and traditional TTO valuations

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Offer Details: Time trade-off Valuation Identity. Digital Object Identifier (DOI) 10.1007/s11136-016-1242-5; PubMed ID . 26875190 Additional Document Info. start page . 2101 end page . 2108 volume . 25 issue ... See more ...

Stability of additive treatment effects in multiple

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Offer Details: The two models are comparably advantageous in terms of a bias-precision trade-off when additivity is only mildly violated. When additivity is strongly violated, the additive effects model is statistically inferior. See more ...

Journal of Clinical Epidemiology - McMaster Experts

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Offer Details: The standard gamble showed better construct validity than the time trade-off. 60:1029-1033. 2007; Systematic reviewers neglect bias that results from trials stopped early for benefit. 60:869-873. 2007; Effect sizes can be calculated for studies reporting ranges for outcome variables in systematic reviews See more ...

Interventions for preventing, delaying the onset, or

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Offer Details: The evidence brief will then be used as the input into a stakeholder dialogue, which will engage 18-22 Canadian health-system leaders (including policymakers, health providers, researchers, and other stakeholders) in 'off-the-record' deliberations to inform future actions and policymaking. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015022082. See more ...

New England Journal of Medicine - McMaster Experts

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Offer Details: Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer . 380:2395-2405. 2019. Aspiration Pneumonia . 380:e40-e40. 2019. Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers . 380:1825-1833. 2019. The RACE to Treat Atrial Fibrillation in the Emergency Department . 380:1578-1579. 2019. See more ...

Injury in Brazilian Jiu-Jitsu Training - McMaster Experts

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Offer Details: Participants required to take more than 4 months off training were 5.5 times more likely to consider quitting compared with those who took less time off (OR, 5.48; 95% CI, 2.25-13.38). Conclusion: The prevalence of injury is very high among BJJ practitioners, with 9 of 10 practitioners sustaining at least 1 injury, commonly during training. See more ...

Cardiopulmonary Bypass - McMaster Experts

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Offer Details: Conversion after off-pump coronary artery bypass grafting: the CORONARY trial experience Academic Article Coronary Bypass Surgery Performed off Pump Does Not Result in Lower In-Hospital Morbidity Than Coronary Artery Bypass Grafting Performed on Pump Academic Article Coronary artery bypass grafting in octogenarians. See more ...

Persistent Impairments in Humoral and Cellular Immunity in

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Offer Details: abstract . Abstract Abstract 492 Background: The anti-CD20 antibody, rituximab, is increasingly being used as a treatment for immune thrombocytopenia (ITP). The concern about rare occurrences of progressive multifocal leukoencephalopathy in this population and the reliance on vaccine responses in patients who ultimately require splenectomy calls for additional studies into the integrity of the ... See more ...

Inflammatory biomarkers as independent prognosticators of

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Offer Details: Jan 26, 2021 · We provide early estimates of cut-off values for inflammatory biomarkers and indices measured at the time of admission that may be useful to clinicians for predicting 28-day mortality in North American COVID-19 patients. See more ...

Sub-decibel silicon grating couplers based on L-shaped

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Offer Details: Sep 02, 2019 · In this work, we propose a rather simpler in design of efficient off-chip fiber couplers that provide a simulated efficiency up to 95% (-0.25 dB) at a wavelength of 1.55 µm. These grating couplers are formed with an L-shaped waveguide profile and synthesized subwavelength grating metamaterials. See more ...

Association of Low Back Pain, Impairment, Disability

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Offer Details: Nurses (n = 100) were classified into either off/modified work (due to LBP) or regular work groups. Trunk ROM, trunk muscular endurance, pain and disability were measured relative to the outcomes work status and Work Limitations Questionnaire (WLQ) score. RESULTS: Regression analyses which included Roland Morris Questionnaire (RMQ, disability ... See more ...

Use of different d-dimer levels to exclude venous

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Offer Details: The D-dimer cut-off point for those with moderate clinical pretest probability remained unchanged [0.5 fibrinogen equivalent units (FEU) microgram mL(-1)]. Accuracy of D-dimer testing for venous thromboembolism using three cut-off points vs. one cut-off point was than determined. See more ...

NMDA-receptor Antagonism in Pediatric Pancreatitis: Use of

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Offer Details: Off-Label Use Pain Management Pain Measurement Pain, Intractable Pancreatitis Receptors, N-Methyl-D-Aspartate Identity. Digital Object Identifier (DOI) 10.1097/mpg.0000000000001907; PubMed ID . 29394214 Additional Document Info. start page . e134 end page . e136 ... See more ...

13C Urea Breath Test for Helicobacter pylori

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Offer Details: When replacing the calculated cut-off points by a practical cut-off point of 3.0 δ‰, the risk of false-positive and false-negative results was lower than 2.3%. The 13 C UBT showed 100% sensitivity and 98.5% specificity compared with histology and microbiology (n=176) for … See more ...

Health Policy & Services - McMaster Experts

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Offer Details: A Time Trade-off-derived Value Set of the EQ-5D-5L for Canada Academic Article A brief 5-item version of the Neck Disability Index shows good psychometric properties Academic Article A catalyst for system change: a case study of child health network formation, evolution and … See more ...

Genetic Dissection of Behavior: Modulation of Locomotion

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Offer Details: Modulation of locomotion can be measured as a reduction in the distance traveled and by a sharp change of direction when the light is turned on. When the light is turned off this change of direction, albeit significantly smaller than when the light is turned on, is still significantly larger than in … See more ...

Single-Blind Method - McMaster Experts

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Offer Details: Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days Academic Article Omentectomy added to Roux-en-Y gastric bypass surgery: a randomized, controlled trial Academic Article Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden Academic Article See more ...

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